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Indicated for: Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome (as adjunctive therapy to continuous positive airway pressure), Shift Work Sleep Disorder, Headache, Nausea, Anxiety, Dizziness, Insomnia, Diarrhea.

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British investigators have demonstrated that the 100 mg dosage is particularly suitable for elderly patients and those with hepatic impairment, in whom prolonged drug clearance results in extended duration of effect from reduced doses. In the United Kingdom, the Medicines and Healthcare products Regulatory Agency approved summary of product characteristics for modafinil specifies 200 mg once daily as the recommended dosage for all approved indications, based on the integrated analysis of clinical trial data demonstrating maximum therapeutic separation from placebo at this exposure level. American clinical pharmacologists emphasize that the elimination half-life of modafinil is ten to twelve hours, meaning that approximately fifty percent of an administered dose remains in the body at ten to twelve hours post-dosing, and that redosing before significant drug elimination has occurred risks cumulative drug exposure and dose-dependent adverse effects. Kamagra 100mg Achat. British sleep physicians advise patients to establish a regular medication routine, using reminder systems and linking dose administration to established daily habits to prevent missed doses and maintain consistent therapeutic coverage.

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